EADC

Research projects

The steering committee will decide which projects will be put before the EC for funding.
Details of proposed future studies should be sent to the EADC coordinator at least 2 weeks prior to each consortium meeting.

Initially the consortium will aim to maintain 3 research projects annually. This workload may be varied depending on the intensity and urgency of each project.

The centre proposing the project will remain as principle investigator throughout the project and will have all responsibilities from submission of grant application to presentation of results.

Each project will use the expertise of the Consortium for advise, data management and ethics and public awareness.
Research projects will be funded by:

  • Public funding at either national or European level
  • A combination of public and industry funding
  • Pharmaceutical industry funding.

This type of study will comply with EADC guidelines about collaboration with the pharmaceutical industry. Except in exceptional circumstances a maximum of one study per year will be undertaken in this category by the consortium.


FUNDED

Project: Harmonization of protocols for the manual segmentation of the hippocampus: an EADC-ADNI joint effort.
Website: www.hippocampal-protocol.net

Publications:
  -   Frisoni GB, Jack CR. - Harmonization of magnetic resonance-based manual hippocampal segmentation: A mandatory step for wide clinical use. - Alzheimer's & Dementia, Volume 7, Issue 2, Pages 171-174, March 2011.
  -   Jack CR, Barkhof F, Bernstein MA, Cantillon M, Cole PE, DeCarli C, Dubois B, Duchesne S, Fox NC, Frisoni GB, Hampel H, Hill DLG, Johnson K, Mangin J, Scheltens P, Schwarz AJ, Sperling R, Suhy J, Thompson PM, Weiner M, Foster NL. - Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease. - Alzheimer's & Dementia, Volume 7, Issue 4, Pages 474-485, July 2011.
  -   Boccardi M, Ganzola R, Bocchetta M, Pievani M, Redolfi A, Bartzokis G, Camicioli R, Csernansky J, de Leone MJ, deToledo-Morrell L, Killiany RJ, Lehericy S, Pantel J, Pruessner JC, Soininen H, Watson C, Duchesne S, Jack CR Jr, Frisoni GB. - Survey of Protocols for the Manual Segmentation of the Hippocampus: Preparatory Steps Towards a Joint EADC-ADNI Harmonized Protocol. - Journal of Alzheimer's Disease, Volume 26, Issue 0, Pages 61-75, January 2011.
  -   Boccardi M, Bocchetta M, Ganzola R, Robitaille N, Redolfi A, Duchesne S, Jack CR Jr, Frisoni GB, for the EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry. - Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation. - 2012, submitted to Alzheimer’s and Dementia.

SPONTANEOUS

Project: European Alzheimer Consortium PET project (EAPP).
Files:
  -   Participating EADC Centres
  -   Confidential Disclosure Agreement
  -   Enrollment
  -   The European Alzheimer Disease Consortium (EADC) – PET PROJECT (EAPP)
  -   European Alzheimer Disease Consortium (EADC) – Neuroimaging study group

Publications:
  -   Caroli A, Prestia A, Chen K, Ayutyanont N, Landau SM, Madison CM, Haense C, Herholz K, Nobili F, Reiman EM, Jagust WJ, Frisoni GB; and the EADC-PET Consortium, NEST-DD, and Alzheimer's Disease Neuroimaging Initiative - Summary Metrics to Assess Alzheimer Disease-Related Hypometabolic Pattern with 18F-FDG PET: Head-to-Head Comparison - J Nucl Med. 2012 Apr;53(4):592-600. Epub 2012 Feb 17.
  -   Morbelli S, Drzezga A, Perneczky R, Frisoni GB, Caroli A, van Berckel BN, Ossenkoppele R, Guedj E, Didic M, Brugnolo A, Sambuceti G, Pagani M, Salmon E, Nobili F - Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project - Neurobiol Aging. 2012 Feb 22.
  -   Vos SJ, Verhey F, Frölich L, Kornhuber J, Wiltfang J, Maier W, Peters O,Rüther E, Nobili F, Morbelli S, Frisoni GB, Drzezga A, Didic M, van Berckel BN,Simmons A, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S,Muscio C, Herukka SK, Salmon E, Bastin C, Wallin A, Nordlund A, de Mendonça A,Silva D, Santana I, Lemos R, Engelborghs S, Van der Mussele S; Alzheimer’s Disease Neuroimaging Initiative, Freund-Levi Y, Wallin ÅK, Hampel H, van der Flier W, Scheltens P, Visser PJ - Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage - Brain. 2015 May; 138(Pt 5):1327-38. doi: 10.1093/brain/awv029. PubMed PMID: 25693589; PubMed Central PMCID: PMC5013930.
  -   Pagani M, De Carli F, Morbelli S, Öberg J, Chincarini A, Frisoni GB, Galluzzi S, Perneczky R, Drzezga A, van Berckel BN, Ossenkoppele R, Didic M, Guedj E, Brugnolo A, Picco A, Arnaldi D, Ferrara M, Buschiazzo A, Sambuceti G, Nobili F - Volume of interest-based [18F]fluorodeoxyglucose PET discriminates MCI converting to Alzheimer's disease from healthy controls. A European Alzheimer's Disease Consortium (EADC) study - Neuroimage Clin. 2014 Nov 18; 7:34-42. doi: 10.1016/j.nicl.2014.11.007. PubMed PMID: 25610765; PubMed Central PMCID: PMC4299956.
  -   Gallivanone F, Della Rosa PA, Perani D, Gilardi MC, Castiglioni I; EADC-PET Consortium - The impact of different 18FDG PET healthy subject scans for comparison with single patient in SPM analysis - Q J Nucl Med Mol Imaging 2017 Mar; 61(1):115-132. doi: 10.23736/S1824-4785.16.02749-7. PubMed PMID: 25479418.
  -   Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappatà S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium - Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting - Neuroimage Clin. 2014 Oct 24; 6:445-54. doi: 10.1016/j.nicl.2014.10.009. PubMed PMID: 25389519; PubMed Central PMCID: PMC4225527.
  -   Morbelli S, Brugnolo A, Bossert I, Buschiazzo A, Frisoni GB, Galluzzi S, van Berckel BN, Ossenkoppele R, Perneczky R, Drzezga A, Didic M, Guedj E, Sambuceti G, Bottoni G, Arnaldi D, Picco A, De Carli F, Pagani M, Nobili F - Visual versus semi-quantitative analysis of 18F-FDG-PET in amnestic MCI: an European Alzheimer's Disease Consortium (EADC) project - J Alzheimers Dis. 2015;44(3):815-26. doi: 10.3233/JAD-142229. PubMed PMID: 25362041.
  -   Della Rosa PA, Cerami C, Gallivanone F, Prestia A, Caroli A, Castiglioni I, Gilardi MC, Frisoni G, Friston K, Ashburner J, Perani D; EADC-PET Consortium - A standardized [18F]-FDG-PET template for spatial normalization in statistical parametric mapping of dementia - Neuroinformatics. 2014 Oct;12(4):575-93. doi: 10.1007/s12021-014-9235-4. PubMed PMID: 24952892.
  -   Morbelli S, Perneczky R, Drzezga A, Frisoni GB, Caroli A, van Berckel BN, Ossenkoppele R, Guedj E, Didic M, Brugnolo A, Naseri M, Sambuceti G, Pagani M, Nobili F - Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project - J Nucl Med. 2013 Jun;54(6):894-902. doi: 10.2967/jnumed.112.113928. PubMed PMID: 23591639.


Since 2015 12 EADC centers are merging together amyloid PET scans and pertinent clinical data in normal subjects, MCI patients and patients with dementia. The first analyses and results will be ready in the course of 2017.

Project: Hippocampal Volumetry Project (HiVoP).
Files:
  -   Description
  -   Participants